Neuropathological Assessment in Acute Neurotoxic States. the “dark” Neuron
نویسنده
چکیده
Pathological examination of the nervous system is an important component of neurotoxicology, but features of the brain and spinal cord can make this assessment challenging. Among these are the cellular complexity, regional variation of structure and function and multiplicity of reactions to injury of these organs. In addition, there is a propensity for histological artifacts to occur in nervous system tissue samples without scrupulous attention to dissection, sampling, fixation, processing, sectioning and staining of this material. Since artifacts are so common, neurotoxicologists need to be aware of their nature, and avoid misinterpreting these often confusing changes.
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